Differential Effects of CORM-2 and CORM-401 in Murine Intestinal Epithelial MODE-K Cells under Oxidative Stress
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منابع مشابه
Differential Effects of CORM-2 and CORM-401 in Murine Intestinal Epithelial MODE-K Cells under Oxidative Stress
Carbon monoxide (CO)-releasing molecules (CO-RMs) are intensively studied to provide cytoprotective and anti-inflammatory effects of CO in inflammatory conditions including intestinal inflammation. The water-soluble CORM-A1 reduced apoptosis and NADPH oxidase (NOX)-derived reactive oxygen species (ROS) induced by tumor necrosis factor (TNF)-α/cycloheximide (CHX) in mouse MODE-K intestinal epith...
متن کاملAntioxidant potential of CORM-A1 and resveratrol during TNF-α/cycloheximide-induced oxidative stress and apoptosis in murine intestinal epithelial MODE-K cells.
Targeting excessive production of reactive oxygen species (ROS) could be an effective therapeutic strategy to prevent oxidative stress-associated gastrointestinal inflammation. NADPH oxidase (NOX) and mitochondrial complexes (I and II) are the major sources of ROS production contributing to TNF-α/cycloheximide (CHX)-induced apoptosis in the mouse intestinal epithelial cell line, MODE-K. In the ...
متن کاملThe role of CORM-2 as a modulator of oxidative stress and hemostatic parameters of human plasma in vitro
PURPOSE The main aim of the experiment is to examine the effect of CORM-2, a donor of carbon monoxide (CO), on oxidative stress in human plasma in vitro. In addition, it examines the effects of CORM-2 on the hemostatic parameters of plasma: the activated partial thromboplastin time (APTT), thrombin time (TT) and prothrombin time (PT). METHODS Human plasma was incubated for 5-60 min with diffe...
متن کاملEffect of corm size and plant population density on corm yield of Taro (Colocasia Esculenta L.)
Taro (ColocasiaesculentaL. Schott) is a perennial root crop that belongs to Araceace family. It is widely cultivated as a staple food in Africa, Asia and pacific Islands. Despite its importance, there is limited information on many aspects of the crop. In order to obtain data that can support improved and sustainable taro production, a field trial was conducted to study the effects of ...
متن کاملEffect of Corm Size and Plant Population Density on Corm Yield of Taro (Colocasia Esculenta L.)
Objective: Taro (Colocasia esculenta L. Schott) is a perennial root crop that belongs to Araceace family. It is widely cultivated as a staple food in Africa, Asia and pacific Islands. Despite its importance, there is limited information on many aspects of the crop. In order to obtain data that can support improved and sustainable taro production, a field trial was conducted to study t...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2017
ISSN: 1663-9812
DOI: 10.3389/fphar.2017.00031